Role of Akt signaling in vascular homeostasis and angitogenesis

被引:874
作者
Shiojima, I [1 ]
Walsh, K [1 ]
机构
[1] Boston Univ, Sch Med, Mol Cardiol CVI, Whitaker Cardiovasc Inst, Boston, MA 02118 USA
关键词
Akt; endothelial cells; angiogenesis; statins; endothelial nitric oxide synthase;
D O I
10.1161/01.RES.0000022200.71892.9F
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since the identification of several classes of receptor tyrosine kinases and their ligands as crucial mediators of vascular development, considerable progress has been made toward understanding the process of angiogenesis at sites of tissue growth and/or repair.(1,2) A number of clinical trials are currently evaluating angiogenic ligands for their ability to induce neovascularization in ischemic tissues 3,4 and the intracellular signaling pathways that mediate the proangiogenic effects of these growth factors are being extensively investigated. This review specifically focuses on the role of phosphatidylinositol-3 kinase (PI3K)-Akt signaling axis in endothelial cells because it is activated by many angiogenic growth factors and it regulates downstream target molecules that are potentially involved in blood vessel growth and homeostasis.
引用
收藏
页码:1243 / 1250
页数:8
相关论文
共 145 条
  • [1] 3 Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
    Alessi, DR
    Kozlowski, MT
    Weng, QP
    Morrice, N
    Avruch, J
    [J]. CURRENT BIOLOGY, 1998, 8 (02) : 69 - 81
  • [2] VASCULAR ENDOTHELIAL GROWTH-FACTOR ACTS AS A SURVIVAL FACTOR FOR NEWLY FORMED RETINAL-VESSELS AND HAS IMPLICATIONS FOR RETINOPATHY OF PREMATURITY
    ALON, T
    HEMO, I
    ITIN, A
    PEER, J
    STONE, J
    KESHET, E
    [J]. NATURE MEDICINE, 1995, 1 (10) : 1024 - 1028
  • [3] Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
    Altomare, DA
    Lyons, GE
    Mitsuuchi, Y
    Cheng, JQ
    Testa, JR
    [J]. ONCOGENE, 1998, 16 (18) : 2407 - 2411
  • [4] ALTOMARE DA, 1995, ONCOGENE, V11, P1055
  • [5] Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training
    Amaral, SL
    Papanek, PE
    Greene, AS
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (03): : H1163 - H1169
  • [6] Cytoskeletal effects of Rho-like small guanine nucleotide-binding proteins in the vascular system
    Amerongen, GPV
    van Hinsbergh, VWM
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (03) : 300 - 311
  • [7] THE EFFECT OF CHOLESTEROL-LOWERING AND ANTIOXIDANT THERAPY ON ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION
    ANDERSON, TJ
    MEREDITH, IT
    YEUNG, AC
    FREI, B
    SELWYN, AP
    GANZ, P
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (08) : 488 - 493
  • [8] Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
    Andjelkovic, M
    Jakubowicz, T
    Cron, P
    Ming, XF
    Han, JW
    Hemmings, BA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) : 5699 - 5704
  • [9] The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis
    Bachelder, RE
    Wendt, MA
    Fujita, N
    Tsuruo, T
    Mercurio, AM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) : 34702 - 34707
  • [10] PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
    Balendran, A
    Casamayor, A
    Deak, M
    Paterson, A
    Gaffney, P
    Currie, R
    Downes, CP
    Alessi, DR
    [J]. CURRENT BIOLOGY, 1999, 9 (08) : 393 - 404