Updates in perioperative coagulation: physiology and management of thromboembolism and haemorrhage

被引：55

作者：

Bombeli, T

Spahn, DR

机构：

[1] Univ Lausanne Hosp, Dept Anaesthesiol, CH-1011 Lausanne, Switzerland

[2] Univ Zurich Hosp, Div Haematol, Coagulat Lab, CH-8091 Zurich, Switzerland

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2004年 / 93卷 / 02期

关键词：

blood; coagulation; complications; haemorrhage; thromboembolism;

D O I：

10.1093/bja/aeh174

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Understanding of blood coagulation has evolved significantly in recent years. Both new coagulation proteins and inhibitors have been found and new interactions among previously known components of the coagulation system have been discovered. This increased knowledge has led to the development of various new diagnostic coagulation tests and promising antithrombotic and haemostatic drugs. Several such agents are currently being introduced into clinical medicine for both the treatment or prophylaxis of thromboembolic disease and for the treatment of bleeding. This review aims to elucidate these new concepts and to outline some consequences for clinical anaesthesia and perioperative medicine.

引用

页码：275 / 287

页数：13

共 110 条

[1]

Aledort LM, 2000, THROMB HAEMOSTASIS, V83, P637

[2] Antifibrinolytic therapy and perioperative blood loss in cancer patients undergoing major orthopedic surgery [J].