Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

被引：9

作者：

Vargas, JD ^{[1
]}

Culetto, E ^{[1
]}

Ponting, CP ^{[1
]}

Miguel-Aliaga, I ^{[1
]}

Davies, KE ^{[1
]}

Sattelle, DB ^{[1
]}

机构：

[1] Univ Oxford, MRC Funct Genet Unit, Dept Human Anat & Genet, Oxford OX1 3QX, England

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 117卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

transglutaminase domain; LIM domain; green fluorescent protein; epithelial cells; Caenorhabditis elegans; kyphoscoliosis; ky gene; development; hypodermal cells; human genetic diseases; seam cells; socket cells; pharynx;

D O I：

10.1016/S0925-4773(02)00182-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：289 / 292

页数：4

共 15 条

[1] The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein [J].

Blanco, G ;

Coulton, GR ;

Biggin, A ;

Grainge, C ;

Moss, J ;

Barrett, M ;

Berquin, A ;

Maréchal, G ;

Skynner, N ;

van Mier, P ;

Nikitopoulou, A ;

Kraus, M ;

Ponting, CP ;

Mason, RM ;

Brown, SDM .

HUMAN MOLECULAR GENETICS, 2001, 10 (01) :9-16

[2]

BRENNER S, 1974, GENETICS, V77, P71

[3] THE NEUROMUSCULAR BASIS OF HEREDITARY KYPHOSCOLIOSIS IN THE MOUSE [J].

BRIDGES, LR ;

COULTON, GR ;

HOWARD, G ;

MOSS, J ;

MASON, RM .

MUSCLE & NERVE, 1992, 15 (02) :172-179

[4] GREEN FLUORESCENT PROTEIN AS A MARKER FOR GENE-EXPRESSION [J].

CHALFIE, M ;

TU, Y ;

EUSKIRCHEN, G ;

WARD, WW ;

PRASHER, DC .

SCIENCE, 1994, 263 (5148) :802-805

[5] Form of the worm:: genetics of epidermal morphogenesis in C-elegans [J].

Chin-Sang, ID ;

Chisholm, AD .

TRENDS IN GENETICS, 2000, 16 (12) :544-551

[6] The role of actin filaments in patterning the Caenorhabditis elegans cuticle [J].

Costa, M ;

Draper, BW ;

Priess, JR .

DEVELOPMENTAL BIOLOGY, 1997, 184 (02) :373-384

[7] A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo [J].

Costa, M ;

Raich, W ;

Agbunag, C ;

Leung, B ;

Hardin, J ;

Priess, JR .

JOURNAL OF CELL BIOLOGY, 1998, 141 (01) :297-308

[8] A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes [J].

Culetto, E ;

Sattelle, DB .

HUMAN MOLECULAR GENETICS, 2000, 9 (06) :869-877

[9] CHROMA: consensus-based colouring of multiple alignments for publication [J].

Goodstadt, L ;

Ponting, CP .

BIOINFORMATICS, 2001, 17 (09) :845-846

[10] Molecular identification and sequence analysis of Hillarin, a novel protein localized at the axon hillock [J].

Ji, Y ;

Schroeder, D ;

Byrne, D ;

Zipser, B ;

Jellies, J ;

Johansen, KM ;

Johansen, J .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2001, 1519 (03) :246-249

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