Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza

被引：39

作者：

Ko, JS

Ryu, SY

Kim, YS

Chung, MY

Kang, JS

Rho, MC

Lee, HS

Kim, YK

机构：

[1] Korea Res Inst Biosci & Biotechnol, Cardiovasc Res Lab, Taejon 305600, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[3] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2002年 / 25卷 / 04期

关键词：

Salvia miltiorrhiza; labiatae; tanshinones; diacylglycerol acyltransferase;

D O I：

10.1007/BF02976599

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone 1 (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 mug/ml and 11.1 mug/ml. However, tanshinone IIA (2) and tanshinone 1 (4) showed very weak inhibition (IC50 value: > 250 mug/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity.

引用

页码：446 / 448

页数：3

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