Practical, highly active, and enantioselective ferrocenyl-imidazoline palladacycle catalysts (FIPs) for the aza-claisen rearrangement of N-para-methoxyphenyl trifluoroacetimidates

被引：125

作者：

Weiss, Matthias E. ^{[1
]}

Fischer, Daniel F. ^{[1
]}

Xin, Zhuo-Qun ^{[1
]}

Jautze, Sascha ^{[1
]}

Schweizer, W. Bernd ^{[1
]}

Peters, Ren ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 34期

关键词：

aza-Claisen rearrangement; cyclopalladation; ferrocene; imidazoline; Overman rearrangement;

D O I：

10.1002/anie.200601731

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Just a pinch of catalyst: Just 0.05 mol % of a novel planar chiral ferrocenyl-imidazoline palladacycle catalyst (FIP) is sufficient to catalyze a highly efficient aza-Claisen rearrangement of N-para-methoxyphenyl trifluoroacetimidates and thereby provide access to chiral protected primary allylic amines with unprecedentedly high enantioselectivities (see scheme). (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5694 / 5698

页数：5

共 18 条

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