Unsymmetrical hybrid ferrocene-based phosphine-phosphoramidites: A new class of practical Ligands for Rh-catalyzed asymmetric hydrogenation

被引：97

作者：

Hu, XP ^{[1
]}

Zheng, Z ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 20期

关键词：

D O I：

10.1021/ol048519d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and application of a new family of air-stable, highly unsymmetrical ferrocene-based phosphine-phosphoramidites is described. The new ligands exhibit excellent enantioselectivities (over 99% ee) in the Rh-catalyzed asymmetric hydrogenation of enamides, dimethyl itaconate, and methyl (Z)-acetamidocinnamate even with high catalyst turnovers (S/C = 10 000). The binaphthyl moiety is crucial for reactivity and enantioselectivity, and its absolute configuration plays a dominant role in determining the chirality of the hydrogenation products.

引用

页码：3585 / 3588

页数：4

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