Lunasin abrogates the expression of matrix metalloproteinases and reduction of type II collagen

被引：15

作者：

Dai, Weihua ^{[1
]}

Liang, Zhiyong ^{[1
]}

Liu, Hongbo ^{[1
]}

Zhao, Guangzong ^{[1
]}

Ju, Chunfang ^{[2
]}

机构：

[1] Weifang Yidu Cent Hosp, Dept Orthoped, Weifang, Shandong, Peoples R China

[2] Weifang Peoples Hosp, Dept Orthoped, Weifang, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2019年 / 47卷 / 01期

关键词：

Osteoarthritis; lunasin; matrix metalloproteinases; type II collagen; CANCER CELLS; NANOPARTICLES; ACTIVATION; EXTRACT; MMP-3;

D O I：

10.1080/21691401.2019.1623227

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Impairment of type H collagen caused by MMPs in response to overproduction of IL-1 beta is an important step in the pathological progression of osteoarthritis (OA). Lunasin, a well-known peptide present in the soybean, has displayed a positive impact on numerous physiological functions. Little information in the effects of lunasin on cartilage degradation has been sought in clinical research before. Here, we report that lunasin suppressed the increase in MMP-3 and MMP-13 caused by IL-1 beta. In addition, we found that lunasin could prevent the decrease in TIMP-1 and TIMP-2 expressions caused by IL-1 beta. Notably, lunasin suppressed reduction of type II collagen, the basis for articular cartilage. Lunasin also attenuated activation of the JAK2/STAT1/IRF-1 pathway. These effects of lunasin suggest that it might become a promising therapeutic agent for chondro-protective therapy.

引用

页码：3259 / 3264

页数：6

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