Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease

被引：39

作者：

Chen, Yanjia ^{[1
,2
]}

Han, Hui ^{[1
,2
]}

Yan, Xiaoxiang ^{[1
]}

Ding, Fenghua ^{[1
]}

Su, Xiuxiu ^{[1
]}

Wang, Haibo ^{[2
]}

Chen, Qiujing ^{[2
]}

Lu, Lin ^{[1
,2
]}

Zhang, Ruiyan ^{[1
,2
]}

Jin, Wei ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Cardiol, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Inst Cardiovasc Dis, Shanghai 200030, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

SERUM TETRANECTIN; BINDING-PROTEIN; PLASMINOGEN; ATHEROSCLEROSIS; COAGULATION;

D O I：

10.1038/srep17632

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

This cross-sectional study tested the hypothesis that decreased serum levels of tetranectin (TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence and severity of CAD. We conducted a systematic serological and immunohistochemical (IHC) analysis to respectively compare the TN levels in serum and artery samples in CAD patients and healthy controls. Our results showed that serum levels of TN were significantly lower in patients with CAD than in healthy controls. Further analysis via trend tests revealed that serum TN levels correlated with the number of diseased arteries. Besides, the multivariate logistic regression model revealed TN as an independent factor associated with the presence of CAD. Additionally, IHC analysis showed that TN expression was significantly higher in atherosclerotic arteries as compared to healthy control tissues. In conclusion, our study suggests that increased serum TN level is associated with the presence and severity of diseased coronary arteries in patients with stable CAD.

引用

页数：8

共 27 条

[1]

Coagulation and atherothrombotic disease [J].