Synthesis and DNA binding of spirocyclic model compounds related to the neocarzinostatin chromophore

被引：47

作者：

Xi, Z

Jones, GB ^{[1
]}

Qabaja, G

Wright, J

Johnson, F

Goldberg, IH

机构：

[1] Northeastern Univ, Dept Chem, Bioorgan & Med Chem Labs, Boston, MA 02115 USA

[2] SUNY Stony Brook, Dept Pharmacol Sci, Stony Brook, NY 11794 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 09期

关键词：

D O I：

10.1021/ol9909280

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

[GRAPHICS] Spirocyclic model compounds which mimic the molecular architecture of one of the decomposition products of the antitumor agent NCS-chrom have been synthesized. These readily accessible molecules bind with remarkable efficiency to bulged DNA oligonucleotides, offering potential for the design of therapeutic agents.

引用

页码：1375 / 1377

页数：3

共 4 条

[1]

HIGH-PRESSURE DIELS-ALDER REACTIONS OF 2-VINYL-3,4-DIHYDRONAPHTHALENE - SYNTHESIS OF CYCLOPENTA[C]PHENANTHRENONES AND INDENO[C]PHENANTHRENONES [J].