Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)

被引：413

作者：

Baell, Jonathan B. ^{[1
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, Parkville Campus,381 Royal Parade, Parkville, Vic 3084, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 03期

关键词：

POTASSIUM CHANNEL KV1.3; CLINICAL-TRIALS; CRYSTAL-STRUCTURE; TOXICOLOGICAL EVALUATION; CHEMICAL-PROPERTIES; REACTIVE COMPOUNDS; MOLECULAR-BASIS; VITAMIN-K; DISCOVERY; INHIBITORS;

D O I：

10.1021/acs.jnatprod.5b00947

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We have previously reported on classes of compounds that can interfere with bioassays via a number of different mechanisms and termed such compounds Pan Assay INterference compoundS, or PAINS. These compounds were defined on the basis of high-throughput data derived from vendor-supplied synthetics. The question therefore arises whether the concept of PAINS is relevant to compounds of natural origin. Here, it is shown that this is indeed the case, but that the context of the biological readout is an important factor that must be brought into consideration.

引用

页码：616 / 628

页数：13

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