Supercooling enables long-term transplantation survival following 4 days of liver preservation

被引：166

作者：

Berendsen, Tim A. ^{[1
,2
]}

Bruinsma, Bote G. ^{[1
]}

Puts, Catheleyne F. ^{[1
]}

Saeidi, Nima ^{[1
]}

Usta, O. Berk ^{[1
]}

Uygun, Basak E. ^{[1
]}

Izamis, Maria-Louisa ^{[1
]}

Toner, Mehmet ^{[1
]}

Yarmush, Martin L. ^{[1
,3
]}

Uygun, Korkut ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Engn Med, Boston, MA 02163 USA

[2] Univ Med Ctr, Dept Surg, Utrecht, Netherlands

[3] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ USA

来源：

NATURE MEDICINE | 2014年 / 20卷 / 07期

基金：

美国国家卫生研究院;

关键词：

SUBNORMOTHERMIC MACHINE PERFUSION; COLD-STORAGE; UW SOLUTION; RAT-LIVER; CRYOPRESERVATION; GRAFTS; VITRIFICATION; RECOVERY; IMPROVES;

D O I：

10.1038/nm.3588

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The realization of long-term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a new technique based on subzero nonfreezing preservation and extracorporeal machine perfusion that allows transplantation of rat livers preserved for up to four days, thereby tripling the viable preservation duration.

引用

页码：790 / 793

页数：4

共 41 条

[1]

al-Abdulla N A, 1995, Conn Med, V59, P387

[2]

Banafsche R, 1998, TRANSPLANT INT, V11, P127

[3]

PRINCIPLES OF SOLID-ORGAN PRESERVATION BY COLD-STORAGE [J].

BELZER, FO ;

SOUTHARD, JH .

TRANSPLANTATION, 1988, 45 (04) :673-676

[4]

A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation [J].

Berendsen, Tim A. ;

Bruinsma, Bote G. ;

Lee, Jungwoo ;

D'Andrea, Vincent ;

Liu, Qiang ;

Izamis, Maria-Louisa ;

Uygun, Korkut ;

Yarmush, Martin L. .

TRANSPLANTATION RESEARCH, 2012, 1

[5]

Optimization of a new preservation solution for machine perfusion of the liver: Which is the preferred colloid? [J].

Bessems, M ;

Doorschodt, BM ;

Hooijschuur, O ;

van Vliet, AK ;

van Gulik, TM .

TRANSPLANTATION PROCEEDINGS, 2005, 37 (01) :329-331

[6]

Subnormothermic Machine Perfusion for Ex Vivo Preservation and Recovery of the Human Liver for Transplantation [J].

Bruinsma, B. G. ;

Yeh, H. ;

Oezer, S. ;

Martins, P. N. ;

Farmer, A. ;

Wu, W. ;

Saeidi, N. ;

Op den Dries, S. ;

Berendsen, T. A. ;

Smith, R. N. ;

Markmann, J. F. ;

Porte, R. J. ;

Yarmush, M. L. ;

Uygun, K. ;

Izamis, M. -L. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (06) :1400-1409

[7]

Determination and extension of the limits to static cold storage using subnormothermic machine perfusion [J].

Bruinsma, Bote G. ;

Berendsen, Tim A. ;

Izamis, Maria-Louisa ;

Yarmush, Martin L. ;

Uygun, Korkut .

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2013, 36 (11) :775-780

[8]

Dutheil Delphine, 2009, J Chem Biol, V2, P39, DOI 10.1007/s12154-009-0014-x

[9]

Machine perfusion for 'Marginal' liver grafts [J].

Dutkowski, P. ;

de Rougemont, O. ;

Clavien, P. -A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (05) :917-924

[10]

Cryopreservation of organs by vitrification: perspectives and recent advances [J].

Fahy, GM ;

Wowk, B ;

Wu, J ;

Phan, J ;

Rasch, C ;

Chang, A ;

Zendejas, E .

CRYOBIOLOGY, 2004, 48 (02) :157-178

← 1 2 3 4 5 →