Emerging roles of desumoylating enzymes

被引：102

作者：

Kim, Jung Hwa ^{[1
]}

Baek, Sung Hee ^{[2
]}

机构：

[1] Inha Univ, Dept Med Sci, Inchon, South Korea

[2] Seoul Natl Univ, Canc Res Inst, Dept Biol Sci, Seoul, South Korea

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2009年 / 1792卷 / 03期

关键词：

Desumoylation enzyme; SUMO; Ulp; SENP; SUMO isoform; SUMO-SPECIFIC PROTEASE; CONJUGATING ENZYME; STRUCTURAL BASIS; CELL-CYCLE; E3; LIGASE; DEPENDENT TRANSCRIPTION; DIFFERENTIAL REGULATION; UNEXPECTED SPECIFICITY; DECONJUGATING ENZYMES; ANDROGEN RECEPTOR;

D O I：

10.1016/j.bbadis.2008.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse cellular processes including transcriptional regulation, nuclear transport, cell-cycle progression, DNA repair, and signal transduction pathway. Sumoylation is a highly dynamic process that is reversed by a family of Sentrin/SUMO-specific proteases (SENPs). Thus, desumoylation process must be important for regulation of the fate and function of SUMO-conjugated proteins as well as SUMOylation process. SENPs catalyze the removal of SUMO from SUMO-conjugated target proteins as well as the cleavage of SUMO from its precursor proteins. Since the first report of yeast desumoylating enzymes, many studies have revealed the structural and cellular biological properties of SENP family. This review focuses on the specificity of the SENPs' catalytic activities with regard to SUMO isoforms and their emerging roles as cellular regulators. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：155 / 162

页数：8

共 134 条

[1]

The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA Topoisomerase II [J].