Vasopressin induces emesis in Suncus murinus

被引:14
作者
Ikegaya, Y [1 ]
Matsuki, N [1 ]
机构
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Chem Pharmacol Lab, Tokyo 1130033, Japan
关键词
vomit; Suncus; vasopressin;
D O I
10.1254/jjp.89.324
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This paper reports that vasopressin is emetogenic in the house musk shrew Suncus murinus. Either intravenous or intracerebroventricular administration of vasopressin caused vomiting within a few minutes. The ED50 of intravenous vasopressin was as high as 4.67 mug/kg, whereas intracerebroventricularly injected vasopressin was effective at a low dose of 20 ng/brain. The emetogenic target of vasopressin may therefore be present in the central nervous system. We propose the Suncus as a useful animal for investigation of vasopressin-mediated emesis, including motion sickness.
引用
收藏
页码:324 / 326
页数:3
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