Helicobacter pylori enhances cyclooxygenase 2 expression via p38MAPK/ATF-2 signaling pathway in MKN45 cells

被引：58

作者：

Li, Qi ^{[1
]}

Liu, Ningning ^{[1
]}

Shen, Bo ^{[2
]}

Zhou, Lihong ^{[1
]}

Wang, Yan ^{[1
]}

Wang, Yiqin ^{[3
]}

Sun, Jue ^{[1
]}

Fan, Zhongze ^{[1
]}

Liu, Rui Hai ^{[4
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Dept Oncol, Putuo Hosp, Shanghai 200062, Peoples R China

[2] Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Shanghai 200032, Peoples R China

[4] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA

来源：

CANCER LETTERS | 2009年 / 278卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Gastric cancer; Helicobacter pylori; Cyclooxygenase; 2; p38MAPK; Signal transduction; GASTRIC EPITHELIAL-CELLS; NF-KAPPA-B; MONGOLIAN GERBILS; GROWTH-FACTOR; CANCER CELLS; AGS CELLS; ANGIOGENESIS; CARCINOMA; APOPTOSIS; MUCOSA;

D O I：

10.1016/j.canlet.2008.12.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The over-expression of COX-2 (Cyclooxygenase 2) protein has been reported to play a key role in the incidence and development of Helicobacter pylori-associated gastric cancer. The induction of COX-2 in the gastric cancer cells with H. pylon has been demonstrated previously, but little is known about the mechanism. This study reported that the COX-2 mRNA and proteins expression level and the activity of COX-2 promoter increased remarkably with H. pylori stimulation in the MKN45 gastric cancer cells. H. pylori also stimulated phosphorylation of p38MAPK and ATF-2, which is the downstream kinase of p38MAPK. Moreover, the expression levels of COX-2 were suppressed with p38MAPK inhibitor treatment. These results suggest that H. pylori-induced activation of p38MAPK/ATF-2-mediated signal pathway is necessary for the expression of COX-2. Crown Copyright (c) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：97 / 103

页数：7

共 35 条

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Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori [J].