Abnormal histone acetylase and deacetylase expression and function in lung inflammation

被引:30
作者
Adcock, I. M. [1 ]
Lee, K. -Y. [1 ]
机构
[1] Imperial Coll London, Natl Heart & Lung Inst, Airways Dis Sect, London, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1007/s00011-006-0081-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Post-translational modifications in DNA and histone proteins are heritable changes that are not coded for in the DNA sequence itself but play an important role in the control of gene expression. These modifications include histone acetylation, methylation, ubiquitination, sumoylation and phosphorylation. These changes are not only critical for generating diversity of cell types during mammalian development, but are also important for maintaining the stability and integrity of the expression profiles of different cell types. Until recently, the study of human disease has focused on genetic mechanisms rather than on non-coding events. However, it is becoming increasingly clear that altered patterns of histone modifications can lead to several major pathologies. This review focuses on histone acetylation and its role in inflammatory gene expression. Interestingly, the expression and activity of enzymes that regulate this modification have been reported to be abnormal in the airways of patients with respiratory disease. Histone modifications, despite being heritable and stably maintained, are also potentially reversible and there is scope for the development of "epigenetic therapies" for disease.
引用
收藏
页码:311 / 321
页数:11
相关论文
共 124 条
[1]  
Adcock Ian M, 2004, Proc Am Thorac Soc, V1, P247, DOI 10.1513/pats.200402-001MS
[2]   ACETYLATION + METHYLATION OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS [J].
ALLFREY, VG ;
FAULKNER, R ;
MIRSKY, AE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) :786-+
[3]   A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression [J].
Anest, V ;
Hanson, JL ;
Cogswell, PC ;
Steinbrecher, KA ;
Strahl, BD ;
Baldwin, AS .
NATURE, 2003, 423 (6940) :659-663
[4]   The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression [J].
Ashburner, BP ;
Westerheide, SD ;
Baldwin, AS .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (20) :7065-7077
[5]   Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein [J].
Baek, SH ;
Ohgi, KA ;
Rose, DW ;
Koo, EH ;
Glass, CK ;
Rosenfeld, MG .
CELL, 2002, 110 (01) :55-67
[6]   The transcription factor NF-κB and human disease [J].
Baldwin, AS .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (01) :3-6
[7]   Reversing histone methylation [J].
Bannister, AJ ;
Kouzarides, T .
NATURE, 2005, 436 (7054) :1103-1106
[8]   Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases [J].
Barlev, NA ;
Liu, L ;
Chehab, NH ;
Mansfield, K ;
Harris, KG ;
Halazonetis, TD ;
Berger, SL .
MOLECULAR CELL, 2001, 8 (06) :1243-1254
[9]   Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase [J].
Barnes, PJ ;
Ito, K ;
Adcock, IM .
LANCET, 2004, 363 (9410) :731-733
[10]   Theophylline - New perspectives for an old drug [J].
Barnes, PJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (06) :813-818