Cathepsins and compartmentalization in antigen presentation

被引:172
作者
Riese, RJ
Chapman, HA
机构
[1] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1016/S0952-7915(99)00058-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Intracellular trafficking and cell surface expression of MHC class II molecules is a tightly regulated process and is to a large extent, determined by the fate of the class II chaperone, the invariant chain. Inhibition of endosomal proteases critical to invariant chain proteolysis reveals marked shunting of class II complexes to lysosomal compartments. Regulation of endosomal protease activity by expression of cystatin C directs class II cell surface expression during maturation of dendritic cells. These studies highlight the taut interactions between class-II-invariant-chain complexes and endosomal proteases during MHC class II maturation.
引用
收藏
页码:107 / 113
页数:7
相关论文
共 46 条
[1]   Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L [J].
Bevec, T ;
Stoka, V ;
Pungercic, G ;
Dolenc, I ;
Turk, V .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1331-1338
[2]   Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes [J].
Brachet, V ;
Raposo, G ;
Amigorena, S ;
Mellman, I .
JOURNAL OF CELL BIOLOGY, 1997, 137 (01) :51-65
[3]   Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization [J].
Brömme, D ;
Li, ZQ ;
Barnes, M ;
Mehler, E .
BIOCHEMISTRY, 1999, 38 (08) :2377-2385
[4]   Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase [J].
Brown, J ;
Matutes, E ;
Singleton, A ;
Price, C ;
Molgaard, H ;
Buttle, D ;
Enver, T .
LEUKEMIA, 1998, 12 (11) :1771-1781
[5]  
Brown WM, 1997, PROTEIN SCI, V6, P5
[6]  
Bühling F, 1999, AM J RESP CELL MOL, V20, P612
[7]   Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells [J].
Cella, M ;
Engering, A ;
Pinet, V ;
Pieters, J ;
Lanzavecchia, A .
NATURE, 1997, 388 (6644) :782-787
[8]   Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages - Enrichment of cathepsin H in early endosomes [J].
Claus, V ;
Jahraus, A ;
Tjelle, T ;
Berg, T ;
Kirschke, H ;
Faulstich, H ;
Griffiths, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) :9842-9851
[9]   Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment [J].
Coulombe, R ;
Grochulski, P ;
Sivaraman, J ;
Menard, R ;
Mort, JS ;
Cygler, M .
EMBO JOURNAL, 1996, 15 (20) :5492-5503
[10]   Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity [J].
Cygler, M ;
Mort, JS .
BIOCHIMIE, 1997, 79 (11) :645-652