Structure of replicating hepatitis C virus (HCV) quasispecies in the liver may not be reflected by analysis of circulating HCV virions

被引：58

作者：

Cabot, B ^{[1
]}

Esteban, JI ^{[1
]}

Martell, M ^{[1
]}

Genesca, J ^{[1
]}

Vargas, V ^{[1
]}

Esteban, R ^{[1
]}

Guardia, J ^{[1
]}

Gomez, J ^{[1
]}

机构：

[1] UNIV AUTOMA BARCELONA,HOSP GEN UNIV VALL HEBRON,SERV MED INTERNAHEPATOL,DEPT MED,LIVER UNIT,BARCELONA 08035,SPAIN

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 02期

关键词：

D O I：

10.1128/JVI.71.2.1732-1734.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have analyzed the population of hepatitis C virus (HCV) sequences in paired liver and serum samples from four patients with chronic hepatitis C, Sequences from three different biopsy specimens from a liver explant from one patient were compared with each other and with the circulating sequences. Our results demonstrate that the circulating quasispecies does not necessarily reflect the viral population replicating in the liver and that this is not due to a macroscopic anatomic compartmentalization of HCV replication. This finding has important implications for the pathogenesis and natural history of chronic HCV infection.

引用

页码：1732 / 1734

页数：3

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