Molecular evolution of the tet(M) gene in Gardnerella vaginalis

被引:11
作者
Huang, R
GascoyneBinzi, DM
Hawkey, PM
Yu, M
Heritage, J
Eley, A
机构
[1] UNIV LEEDS,DEPT MICROBIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[2] SUZHOU MED COLL,BIOTECHNOL RES INST,SUZHOU 215007,PEOPLES R CHINA
[3] UNIV SHEFFIELD,SCH MED,DEPT MED MICROBIOL,SHEFFIELD S10 2RX,S YORKSHIRE,ENGLAND
关键词
D O I
10.1093/jac/40.4.561
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Five clinical isolates of Gardnerella vaginalis known to carry the tetracycline resistance determinant Tet M were examined by hybridization and nucleotide sequencing. Four of the strains carried tet(M) genes with identical sequences. The two versions of the tet(M) gene found in G. vaginalis did not show complete identity with other published tet(M) sequences, but showed mosaic structures with regions of homology to tet(M) gene sequences from Tn916, Tn 1545 and the American type plasmid found in Neisseria gonorrhoeae. Hybridization studies showed that all isolates carried the tet(M) gene on a single HindII restriction fragment of variable length. No evidence was found for the presence of sequences homologous to the transposition functions of Tn916.
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收藏
页码:561 / 565
页数:5
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