Addition of diethylzinc to dicobalt hexacarbonyl complexes of α,β-acetylenic aldehydes with virtually complete enantioselectivity.: A formal synthesis of (+)-incrustoporin

被引：22

作者：

Fontes, M

Verdaguer, X

Solà, L

Vidal-Ferran, A

Reddy, KS

Riera, A

Pericàs, MA

机构：

[1] URSA, E-08028 Barcelona, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 14期

关键词：

D O I：

10.1021/ol0260268

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The addition of diethylzinc to dicobalt hexacarbonyl complexes of acetylenes mediated by (R)-2-piperidino-1,1,2-triphenylethanol takes place with very high enantioselectivity (96-99% ee) to afford the S enantiomers of dicobalt hexacarbonyl complexes of 1-alkynyl-1-propanols. The utility of this process is exemplified by the development of a short, highly enantioselective (99% ee) synthesis of unnatural incrustoporin.

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页码：2381 / 2383

页数：3

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