Pre-market development times for biologic versus small-molecule drugs

被引：30

作者：

Beall, Reed F. ^{[1
,2
,3
,4
]}

Hwang, Thomas J. ^{[1
,2
]}

Kesselheim, Aaron S. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, PORTAL, Div Pharmacoepidemiol & Pharmacoecon, Dept Med, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Univ Calgary, Cummings Sch Med, Calgary, AB, Canada

[4] Univ Calgary, OBrien Inst Publ Hlth, Calgary, AB, Canada

来源：

NATURE BIOTECHNOLOGY | 2019年 / 37卷 / 07期

关键词：

D O I：

10.1038/s41587-019-0175-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

引用

页码：708 / 711

页数：5

共 20 条

[1]

[Anonymous], 2012, The R&D cost of a new medicine

[2]

[Anonymous], ADV HLTH INN 2017 NE

[3]

[Anonymous], 2018, NOV DRUGS APPR FDA 2

[4]

Beall Reed F, 2019, N Engl J Med, V380, pe12, DOI 10.1056/NEJMp1806930

[5]

A Method for Approximating Future Entry of Generic Drugs [J].

Beall, Reed F. ;

Darrow, Jonathan J. ;

Kesselheim, Aaron S. .

VALUE IN HEALTH, 2018, 21 (12) :1382-1389

[6]

Patent term restoration for top-selling drugs in the United States [J].

Beall, Reed F. ;

Darrow, Jonathan J. ;

Kesselheim, Aaron S. .

DRUG DISCOVERY TODAY, 2019, 24 (01) :20-25

[7]

The Cost of Biopharmaceutical R&D: Is Biotech Different? [J].

DiMasi, Joseph A. ;

Grabowski, Henry G. .

MANAGERIAL AND DECISION ECONOMICS, 2007, 28 (4-5) :469-479

[8]

Timing of patent filing and market exclusivity [J].

Dunn, Michael K. .

NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (07) :487-488

[9]

European Patent Office, 2018, ESP PAT SEARCH

[10]

Evergreening, patent challenges, and effective market life in pharmaceuticals [J].

Hemphill, C. Scott ;

Sampat, Bhaven N. .

JOURNAL OF HEALTH ECONOMICS, 2012, 31 (02) :327-339

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