Characterization of an inhibitor-resistant enzyme IRT-2 derived from TEM-2 beta-lactamase produced by Proteus mirabilis strains

被引：44

作者：

Bret, L ^{[1
]}

Chanal, C ^{[1
]}

Sirot, D ^{[1
]}

Labia, R ^{[1
]}

Sirot, J ^{[1
]}

机构：

[1] MUSEUM NATL HIST NAT,CNRS URA 401,F-75231 PARIS 05,FRANCE

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 38卷 / 02期

关键词：

D O I：

10.1093/jac/38.2.183

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Ten clinical isolates of Proteus mirabilis were found to produce an inhibitor-resistant TEM beta-lactamase (IRT) in association with a TEM-1 enzyme. The IRT enzyme was derived from TEM-2. The bla(IRT) gene differs from bla(TEM-2) gene by one point mutation which leads to the amino-acid substitution Arg --> Ser at position 244, as observed for the original IRT-2 enzyme derived from TEM-1 reported in Escherichia coli. This is the first report of an IRT beta-lactamase derived from TEM-2.

引用

页码：183 / 191

页数：9

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