Microdialysis in adipose tissue and skeletal muscle

被引：25

作者：

Lonnroth, P

机构：

来源：

HORMONE AND METABOLIC RESEARCH | 1997年 / 29卷 / 07期

关键词：

D O I：

10.1055/s-2007-979050

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Traditionally, investigation of metabolism in peripheral tissues such as the adipose tissue and muscles has been done by indirect measurements on whole body metabolism or in cannulated limbs. The microdialysis technique (1) was first invented and further developed (2) by neurobiologists for regional measurements in the rat brain, During the last ten years the technique has been used in several other organs in laboratory animals and since the first application in man (3) it has become wide spread for clinical investigation of human metabolism as well as for clinical pharmacology research, In this article some methodological aspects will be discussed and a few examples of the application of the technique will be given.

引用

收藏

页码：344 / 346

页数：3

相关论文

共 18 条

[1] CONCENTRATIONS OF FREE AMINO ACIDS AND OTHER ELECTROLYTES IN CEREBROSPINAL FLUID IN VIVO DIALYSATE OF BRAIN AND BLOOD PLASMA OF DOG [J].

BITO, L ;

DAVSON, H ;

LEVIN, E ;

MURRAY, M ;

SNIDER, N .

JOURNAL OF NEUROCHEMISTRY, 1966, 13 (11) :1057-&

[2] MICRODIALYSIS MEASUREMENT OF THE ABSOLUTE GLUCOSE-CONCENTRATION IN SUBCUTANEOUS ADIPOSE-TISSUE ALLOWING GLUCOSE MONITORING IN DIABETIC-PATIENTS [J].

BOLINDER, J ;

UNGERSTEDT, U ;

ARNER, P .

DIABETOLOGIA, 1992, 35 (12) :1177-1180

[3] ETHANOL MAY BE USED WITH THE MICRODIALYSIS TECHNIQUE TO MONITOR BLOOD-FLOW CHANGES IN SKELETAL-MUSCLE - DIALYSATE GLUCOSE-CONCENTRATION IS BLOOD-FLOW-DEPENDENT [J].

HICKNER, RC ;

ROSDAHL, H ;

BORG, I ;

UNGERSTEDT, U ;

JORFELDT, L ;

HENRIKSSON, J .

ACTA PHYSIOLOGICA SCANDINAVICA, 1991, 143 (03) :355-356

[4]

HOLMANG A, 1995, DIABETES, V44, pA91

[5] MASS-TRANSFER IN BRAIN DIALYSIS DEVICES - A NEW METHOD FOR THE ESTIMATION OF EXTRACELLULAR AMINO-ACIDS CONCENTRATION [J].

JACOBSON, I ;

SANDBERG, M ;

HAMBERGER, A .

JOURNAL OF NEUROSCIENCE METHODS, 1985, 15 (03) :263-268

[6] CHARACTERIZATION BY MICRODIALYSIS OF INTERCELLULAR GLUCOSE LEVEL IN SUBCUTANEOUS TISSUE IN HUMANS [J].

JANSSON, PA ;

FOWELIN, J ;

SMITH, U ;

LONNROTH, P .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (02) :E218-E220

[7] GLYCEROL PRODUCTION IN SUBCUTANEOUS ADIPOSE-TISSUE IN LEAN AND OBESE HUMANS [J].

JANSSON, PA ;

LARSSON, A ;

SMITH, U ;

LONNROTH, P .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (05) :1610-1617

[8] MEASUREMENT BY MICRODIALYSIS OF THE INSULIN CONCENTRATION IN SUBCUTANEOUS INTERSTITIAL FLUID - IMPORTANCE OF THE ENDOTHELIAL BARRIER FOR INSULIN [J].

JANSSON, PAE ;

FOWELIN, JP ;

VONSCHENCK, HP ;

SMITH, UP ;

LONNROTH, PN .

DIABETES, 1993, 42 (10) :1469-1473

[9]

KENNERGREN C, IN PRESS MICRODIALYS

[10] Microdialysis methodology for the measurement of dermal interstitial fluid in humans [J].

Krogstad, AL ;

Jansson, PA ;

Gisslen, P ;

Lonnroth, P .

BRITISH JOURNAL OF DERMATOLOGY, 1996, 134 (06) :1005-1012