The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

被引：350

作者：

Seenisamy, J

Rezler, EM

Powell, TJ

Tye, D

Gokhale, V

Joshi, CS

Siddiqui-Jain, A

Hurley, LH

机构：

[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[3] Cylene Pharmaceut, San Diego, CA 92121 USA

[4] Arizona Canc Ctr, Tucson, AZ 85724 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 28期

关键词：

D O I：

10.1021/ja040022b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.

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页码：8702 / 8709

页数：8

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