Direct reductive alkylation of amino acids: Synthesis of bifunctional chelates for nuclear imaging

被引：51

作者：

Levadala, MK

Banerjee, SR

Maresca, KP

Babich, JW

Zubieta, J ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

[2] Mol Insight Pharmaceut Inc, Cambridge, MA 02142 USA

来源：

SYNTHESIS-STUTTGART | 2004年 / 11期

关键词：

reductive alkylation; amino acids; bifunctional chelators; radiopharmaceuticals; sodium triacetoxyborohydride;

D O I：

10.1055/s-2004-829120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A family of effective bifunctional chelators for technetium- and rhenium-based radiopharmaceuticals was conveniently synthesized in high yields through direct reductive N-alkylations of amino acids and their analogues with aldehydes, using NaBH(OAc)(3) as an efficient reagent. The mono-, di-, tetra- and even mixed alkylated amino acid derivatives were all prepared in one-pot synthesis.

引用

收藏

页码：1759 / 1766

页数：8

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