Factors associated with bone density in young women with karyotypically normal spontaneous premature ovarian failure

被引：32

作者：

Leite-Silva, Paula ^{[1
]}

Bedone, Aloisio ^{[1
]}

Pinto-Neto, Aarao Mendes ^{[1
]}

Costa, Jose Vilton ^{[1
]}

Costa-Paiva, Lucia ^{[1
]}

机构：

[1] Univ Estadual Campinas, Sch Med, Dept Obstet & Gynaecol, BR-13083881 Sao Paulo, Brazil

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2009年 / 280卷 / 02期

关键词：

Premature ovarian failure; Estrogen deficiency; Bone mineral density; Bone mass; Osteoporosis; MINERAL DENSITY; EARLY MENOPAUSE; FRACTURE RISK; ESTROGEN DEFICIENCY; MASS; HEALTH; DETERMINANTS; ADOLESCENTS; ACQUISITION; FEMALES;

D O I：

10.1007/s00404-008-0881-3

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

To evaluate bone density and associated factors in women with premature ovarian failure (POF) compared to age-matched women with normal ovarian function. A cross-sectional study of 50 patients with POF undergoing bone mineral densitometry was conducted, compared to 50 women paired by age who menstruated regularly. In women with POF, the mean bone mineral density measured was 1.22 g/cm(2) at the spine and 0.92 g/cm(2) at the femur, values which were significantly lower than in the control group (P < 0.0001). Factors directly associated with bone density of the lumbar spine were age and with bone density of the femur were BMI and reproductive age. Young women with POF have a decrease in lumbar spine and femoral bone density. Age, reproductive age and BMI were the factors associated with BMD. These women need early investigation and treatment to prevent bone loss and minimize fracture risk in the future.

引用

页码：177 / 181

页数：5

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