Square wave voltammetric sensing of uric acid using the self-assembly of mercaptobenzimidazole

被引：47

作者：

Raj, CR ^{[1
]}

Kitamura, F ^{[1
]}

Ohsaka, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Interdisciplinary Grad Sch Sci & Engn, Dept Elect Chem, Midori Ku, Yokohama, Kanagawa 2268502, Japan

来源：

ANALYST | 2002年 / 127卷 / 09期

关键词：

D O I：

10.1039/b206703j

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The self-assembled monolayer of a heterocyclic thiol, mercaptobenzimidazole (MBI) on gold (Au) electrode is successfully utilized for the voltammetric sensing of uric acid (UA). The self-assembly of MBI separates the voltammetric signal of UA from the interfering ascorbate (AA). Selective detection of UA in the presence of a large excess of AA or the simultaneous detection of UA and AA is achieved at the MBI monolayer-modified electrode. This electrode can detect as low as 1 m M of UA in the presence of 100-fold excess of AA with excellent reproducibility. The practical utility of the electrode is demonstrated by measuring the concentration of UA in human serum.

引用

页码：1155 / 1158

页数：4

共 20 条

[1]

BERGMEYER HU, 1974, METHOD ENZYMAT AN, V4, P1951

[2] POTENTIAL-DEPENDENT OPENING AND CLOSING OF SELF-ASSEMBLED 2-MERCAPTOBENZTHIAZOLE ON GOLD SUBSTRATES [J].