共 63 条
Inflammation occurs early during the Aβ deposition process in TgCRND8 mice
被引:111
作者:

Dudal, S
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机构:
McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada

Krzywkowski, P
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McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada

Paquette, J
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h-index: 0
机构:
McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada

Morissette, C
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h-index: 0
机构:
McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada

Lacombe, D
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h-index: 0
机构:
McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada

Tremblay, P
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h-index: 0
机构:
McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada

Gervais, F
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h-index: 0
机构:
McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada
机构:
[1] McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2T5, Canada
基金:
加拿大健康研究院;
关键词:
A beta deposition;
inflammation;
Alzheimer's disease;
morphometry;
transgenic mouse;
D O I:
10.1016/j.neurobiolaging.2003.08.008
中图分类号:
R592 [老年病学];
C [社会科学总论];
学科分类号:
03 ;
0303 ;
100203 ;
摘要:
Alzheimer's disease (AD) is characterized by a progressive cognitive decline leading to dementia and involves the deposition of amyloid-beta (Abeta) peptides into senile plaques. Other neuropathological features that accompany progression of the disease include a decrease in synaptic density, neurofibrillary tangles, dystrophic neurites, inflammation, and neuronal cell loss. In this study, we report the early kinetics of brain amyloid deposition and its associated inflammation in an early onset transgenic mouse model of AD (TgCRND8) harboring the human amyloid precursor protein gene with the Indiana and Swedish mutations. Both diffuse and compact plaques were detected as early as 9-10 weeks of age. Abeta-immunoreactive (Abeta-IR) plaques (4G8-positive) appeared first in the neocortex and amygdala, then in the hippocampal formation, and lastly in the thalamus. Compact plaques (ThioS-positive) with an amyloid core were observed as early as diffuse plaques were detected, but in lower numbers. Amyloid deposition increased progressively with age. The formation of plaques was concurrent with the appearance of activated microglial cells and shortly followed by the clustering of activated astrocytes around plaques at 13-14 weeks of age. This TgCRND8 mouse model allows for a rapid, time-dependent study of the relationship between the fibrillogenic process and the inflammatory response during the brain amyloidogenic process. (C) 2003 Published by Elsevier Inc.
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页码:861 / 871
页数:11
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