Doxorubicin accumulation in individually electrophoresed organelles

被引：29

作者：

Anderson, AB ^{[1
]}

Xiong, GH ^{[1
]}

Arriaga, EA ^{[1
]}

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 30期

关键词：

D O I：

10.1021/ja0492539

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude. Copyright © 2004 American Chemical Society.

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页码：9168 / 9169

页数：2

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