Bone-membrane interface in aseptic loosening of total joint arthroplasties

被引：21

作者：

Atkins, RM

Langkamer, VG

Perry, MJ

Elson, CJ

Collins, CMP

机构：

[1] Department of Orthopaedic Surgery, University of Bristol, Bristol

[2] Department of Pathology, University of Bristol, Bristol

[3] Department of Orthopaedic Surgery, Bristol Royal Infirmary

来源：

JOURNAL OF ARTHROPLASTY | 1997年 / 12卷 / 04期

关键词：

aseptic loosening; membrane-bone interface; pseudosynovial membrane; total joint replacement; osteoclast; osteoblast;

D O I：

10.1016/S0883-5403(97)90203-5

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

In 19 patients who underwent revision arthroplasty for aseptic loosening of total joint arthroplasty, specimens were taken at the time of operation to include the bone-membrane interface. In 16 (84%) of the specimens, sufficient visualization of the interface was possible to allow histologic interpretation. In 13 of these cases, there was prominent evidence of classic bone remodeling with osteoclast-mediated resorption and active new bone formation. These results suggest that the osteolysis in aseptic loosening is mediated through osteoclastic bone resorption and that the bone found in such areas is extremely active. The findings help to explain the efficacy of impacted morselized bone-graft in the treatment of bone lysis in aseptic loosening.

引用

页码：461 / 464

页数：4

共 18 条

[1] LOCALIZED ENDOSTEAL BONE LYSIS IN RELATION TO THE FEMORAL COMPONENTS OF CEMENTED TOTAL HIP ARTHROPLASTIES [J].