Effect of spontaneous curvature and sequence disorder on cyclization of fluctuating filaments

被引：11

作者：

Rappaport, S ^{[1
]}

Rabin, Y ^{[1
]}

机构：

[1] Bar Ilan Univ, Dept Phys, IL-52900 Ramat Gan, Israel

来源：

MACROMOLECULES | 2004年 / 37卷 / 21期

关键词：

D O I：

10.1021/ma048320g

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The effect of parameters such as spontaneous curvature and elastic constants of DNA on the conformational properties of the molecules was analyzed. DNA was modeled as a continuous filament which had bending and twist rigidity as well as spontaneous curvature. It was observed that formation of loop was strongly enhanced by the introduction of nonvanishing spontaneous curvature. It was also observed that two independent random distributions of spontaneous curvature gave essentially identical probability of cyclization. The results show that mean curvature determine the looping probability of DNA fragments.

引用

页码：7847 / 7849

页数：3

共 36 条

[1] From the sequence to the superstructural properties of DNAs [J].