Synthesis of indoles using cyclization of imidoyl radicals

被引：18

作者：

Bowman, WR ^{[1
]}

Fletcher, AJ

Lovell, PJ

Pedersen, JM

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] GlaxoSmithKline, Psychiat Med Chem 3, Harlow CM19 5AW, Essex, England

来源：

SYNLETT | 2004年 / 11期

关键词：

radicals; radical reactions; indoles; cyclizations; rearrangements;

D O I：

10.1055/s-2004-830868

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Imidoyl radicals, generated from imidoyl phenylselanide precursors, have been used for the synthesis of 2,3-disubstituted indoles. A facile high yielding synthesis of imidoyl phenylselanides has been developed. The potential for neophyl rearrangement of 5-exo radical intermediates to 6-endo radical intermediates is discussed.

引用

页码：1905 / 1908

页数：4

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