Integration of calcium and Ras signalling

被引：298

作者：

Cullen, PJ ^{[1
]}

Lockyer, PJ ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Biochem, Henry Wellcome Labs Integrated Cell Signalling, Bristol BS8 1TD, Avon, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 05期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrm808

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Calcium is a universal intracellular signal that is responsible for controlling a plethora of cellular processes. Understanding how such a simple ion can regulate so many diverse cellular processes is a key goal of calcium- and cell-biologists. One molecule that is sensitive to changes in intracellular calcium levels is Ras. This small GTPase operates as a binary molecular switch, and regulates cell proliferation and differentiation. Here, we focus on examining the link between calcium and Ras signalling and, in particular, we speculate as to how the complexity of calcium signalling could regulate Ras activity.

引用

页码：339 / 348

页数：10

共 98 条

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[2]

GRFβ, a novel regulator of calcium signaling, is expressed in pancreatic beta cells and brain [J].