Can bioactivity be tested in vitro with SBF solution?

被引：739

作者：

Bohner, Marc ^{[1
]}

Lemaitre, Jacques ^{[2
]}

机构：

[1] RMS Fdn, CH-2544 Bettlach, Switzerland

[2] Ecole Polytech Fed Lausanne, Lab Technol Poudres, CH-1015 Lausanne, Switzerland

来源：

BIOMATERIALS | 2009年 / 30卷 / 12期

关键词：

Bone; Bioactivity; Calcium phosphate; Bioglass; Hydroxyapatite; Simulated body fluid; PHOSPHATE PRECIPITATION; HYDROXYAPATITE; RESORPTION; APATITE; BIOGLASS((R)); REACTIVITY; SATURATION; MECHANISM; BEHAVIOR; PH;

D O I：

10.1016/j.biomaterials.2009.01.008

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A large part of the scientific community has accepted the paradigm that a simulated body solution (SBF) can be used to test the bioactivity of a material. This is exemplified by the rapidly increasing number of publications using this test. The aim of this document is to demonstrate that (i) there is presently not enough scientific data to support this assumption, and (ii) even though the assumption was valid, the way the test is generally conducted leaves room for improvement. Theoretical arguments and facts supporting these statements are provided, together with possible improvements of the proposed bioactivity test. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2175 / 2179

页数：5

共 36 条

[1] In vivo behavior of three different injectable hydraulic calcium phosphate cements [J].