Early genetic changes involved in low-grade astrocytic tumor development

被引：13

作者：

Arjona, Dolores

Rey, Juan Antonio

Taylor, Shirley M.

机构：

[1] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA 23298 USA

[3] Hosp Univ La Paz, Unidad Invest, Lab Oncognet Mol, E-28046 Madrid, Spain

来源：

CURRENT MOLECULAR MEDICINE | 2006年 / 6卷 / 06期

关键词：

low-grade astrocytomas; gene amplification; gene mutation; LOH; promoter hypermethylation;

D O I：

10.2174/156652406778195017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Astrocytomas represent the most common form of glial tumors. The most malignant grade of these tumors, glioblastoma multiforme, may arise as a malignant progression from low-grade astrocytoma through anaplastic astrocytoma to secondary GBM, or else it may arise "de novo" as primary GBM. Both types of glioblastoma are usually histologically indistinguishable. However, distinct molecular alterations have been described between them that potentially allow differentiation between the two mechanisms of origin. Since malignant transformation is a multistep process, we summarize in this review the earliest genetic changes that seem to be involved in the appearance and development of low-grade astrocytic tumors, where early detection and treatment could be possible.

引用

收藏

页码：645 / 650

页数：6

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