Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: The REVEAL study

被引：120

作者：

Cupples, LA

Farrer, LA

Sadovnick, AD

Relkin, N

Whitehouse, P

Green, RC

机构：

[1] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[2] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA

[3] Boston Univ, Sch Med, Dept Med, Genet Program, Boston, MA 02118 USA

[4] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[5] Boston Univ, Sch Med, Dept Genet & Genom, Boston, MA 02118 USA

[6] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada

[7] Univ British Columbia, Fac Med, Div Neurol, Vancouver, BC, Canada

[8] Cornell Univ, Weill Med Coll, Dept Neurol, New York, NY USA

[9] Case Western Reserve Univ, Univ Hosp Cleveland, Memory & Aging Ctr, Cleveland, OH 44106 USA

来源：

GENETICS IN MEDICINE | 2004年 / 6卷 / 04期

关键词：

risk prediction; genetic counseling; Alzheimer's disease;

D O I：

10.1097/01.GIM.0000132679.92238.58

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: The REVEAL study is a randomized, controlled study of the psychological and behavioral impact of APOE disclosure in a risk assessment protocol provided to first degree relatives of patients with Alzheimer's disease. The protocol presents risk information as cumulative incidence curves. This article describes how these curves were estimated. Methods: Curves were calculated using Bayes' rule to compute the posterior survival curves incorporating APOE information. Results: A combination of survival data from the MIRAGE study and gender- and age-specific APOE odds ratios were used to create risk curves for males and females within each of the 6 APOE genotypes. Conclusion: Utilizing comparative genotype relative risk information and survival data from family studies, estimates of gender-, age-, and genotype-specific risk can be generated for use in a risk assessment research study that features genotype disclosure.

引用

页码：192 / 196

页数：5

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