Synthesis of novel bicyclic nucleosides related to natural griseolic acids

被引：10

作者：

Pickering, L ^{[1
]}

Nair, V ^{[1
]}

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 11-12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319608002730

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of novel, bicyclic nucleosides related to natural griseolic acids is described. The synthetic approach involves nucleobase construction at the C-2' position of 1,4:3,6-dianhydro-D-mannitol. The carbohydrate precursor used hi the synthesis, 1,4:3,6-dianhydro-D-glucitol, can be prepared easily from D-glucitol. Bicyclic analogues of five naturally occurring nucleosides have been prepared. The single crystal X-ray structure of a representative example is presented and discussed.

引用

收藏

页码：1751 / 1769

页数：19

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