Plasma leptin association with body composition and energy expenditure in sickle cell disease

被引:11
作者
Buchowski, MS
Simmons, LA
Chen, KY
Flakoll, PJ
Mellen, BG
Turner, EA
机构
[1] Meharry Med Coll, Ctr Nutr, Nashville, TN 37208 USA
[2] Meharry Med Coll, Ctr Comprehens Sickle Cell, Nashville, TN 37208 USA
[3] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
[4] Vanderbilt Univ, Med Ctr, Dept Surg, Nashville, TN USA
[5] Vanderbilt Univ, Med Ctr, Dept Prevent Med, Nashville, TN USA
关键词
leptin; sickle cell disease; resting metabolic rate; body composition;
D O I
10.1080/07315724.2000.10718921
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To examine the association between fasting plasma leptin concentrations and the hypercatobolic state observed in sickle cell disease (SCD). Methods: Plasma leptin concentration and resting energy expenditure (REE) were measured in 37 SCD patients (10 men, 12 boys 14 to 18 years-old seven women, and eight girls 14 to 18 year-old) and in 37 age, Sender and fat mass (FM) matched controls. Body composition was measured hydrostatically, REE by whole room-indirect calorimeter, and plasma leptin using an RIA kit. Results: Plasma leptin concentration and leptin normalized for body fat (ng/dL*kg FM-1) were significantly lower in SCD patients than in non-SCD controls (4.00+/-3.23 vs. 9.94+/-14.69, p=0.021 and 0.406+/-0.260 vs. 0.643+/-0.561, p=0.024, respectively). A positive linear association between log plasma leptin and FM was observed in both males and females, adjusting for age and SCD status. The strength of this association was greater in females compared with males (slope=0.699 and 0.382 log ng/mL per 10 kg FM, respectively: p=0.013). SCD patients an average demonstrated a higher REE, adjusting for FFM (p<0.0001). Log plasma leptin and FM were not statistically significant predictors of REE after adjustment for FFM and SCD, Conclusions: Once corrected for body composition mean plasma leptin concentration was significantly lower among female SCD patients than among non-SCD matched controls. Although REE was higher in SCD patients, there is no simple association between leptin and REE in SCD.
引用
收藏
页码:228 / 236
页数:9
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