Acetate kinase: not just a bacterial enzyme

被引:80
作者
Ingram-Smith, Cheryl [1 ]
Martin, Stephen R. [1 ]
Smith, Kerry S. [1 ]
机构
[1] Clemson Univ, Dept Genet & Biochem, Clemson, SC 29634 USA
关键词
D O I
10.1016/j.tim.2006.04.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The bacterial enzymes acetate kinase (AK) and phosphotransacetylase (PTA) form a key pathway for synthesis of the central metabolic intermediate acetyl coenzyme A (acetyl-CoA) from acetate or for generation of ATP from excess acetyl-CoA. Putative AK genes have now been identified in some eukaryotic microbes. In Chlamydomonas reinhardtii and Phytophthora species, AK forms a pathway with PTA. AK has also been identified in non-yeast fungi but these fungi do not have PTA. Instead, AK forms a pathway with D-Xylulose 5-phosphate phosphoketolase (XFP), a pathway that was also previously found only in bacteria. In Entamoeba histolytica, neither PTA nor XFP was found as a partner for AK. Thus, eukaryotic microbes seem to have incorporated the 'bacterial' enzyme AK into at least three different metabolic pathways.
引用
收藏
页码:249 / 253
页数:5
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