Toward a Mechanism for Biliprotein Lyases: Revisiting Nucleophilic Addition to Phycocyanobilin

被引：13

作者：

Tu, Jun-Ming ^{[1
,2
,3
]}

Zhou, Ming ^{[2
,3
]}

Haessner, Rainer ^{[4
]}

Ploescher, Matthias ^{[1
]}

Eichacker, Lutz ^{[1
]}

Scheer, Hugo ^{[1
]}

Zhao, Kai-Hong ^{[2
,3
]}

机构：

[1] Univ Munich, Dept Biol Bot 1, D-80638 Munich, Germany

[2] Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

[3] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China

[4] Tech Univ Munich, Inst Organ Chem, D-85748 Garching, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 15期

基金：

中国国家自然科学基金;

关键词：

CHROMOPHORE ATTACHMENT; PYRROLE PIGMENTS; BILE-PIGMENTS; PROTEIN; PHYCOERYTHROCYANIN; PHYCOBILIPROTEINS; SPECIFICITY; SUBUNIT; MODEL; PHOTOCHEMISTRY;

D O I：

10.1021/ja9002348

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biliprotein lyases attach linear-tetrapyrrolic bilins covalently to apoproteins, which is a prerequisite for the assembly of phycobiliproteins into phycobilisomes, the light-harvesting complexes of cyanobacteria. On the basis of the addition of thiol and imidazole to phycocyanobilin, we propose a generalized lyase reaction mechanism. The adducts contain isomerized phycocyanobilin that can be transferred by the lyase to apoproteins by either back-isomerization, generating phycocyanobilin-containing proteins, or direct transfer, generating phycoviolobilin-containing proteins.

引用

页码：5399 / +

页数：4

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