Distribution of HLA-B alleles in nasopharyngeal carcinoma patients and normal controls in Thailand

被引：17

作者：

Pimtanothai, N

Charoenwongse, P

Mutirangura, A

Hurley, CK

机构：

[1] Chulalongkorn Univ, Fac Med, Dept Anat, Genet Unit, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Med, Dept Microbiol, Immunol Unit, Bangkok 10330, Thailand

[3] Georgetown Univ, Dept Microbiol & Immunol, Washington, DC USA

来源：

TISSUE ANTIGENS | 2002年 / 59卷 / 03期

关键词：

HLA-B; nasopharyngeal carcinoma;

D O I：

10.1034/j.1399-0039.2002.590308.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-B frequencies in 54 unrelated nasopharyngeal carcinoma (NPC) patients and 49 healthy random controls in Thailand were investigated by direct DNA sequencing. Similar to previous reports in Chinese NPC patients, HLA-B*4601 was observed at a greater frequency in patients (21/54 (40%)) compared to controls (7/49 (14%)). An increase in HLA-B*51012 was also demonstrated. B*51012 was present in 6/54 (11%) NPC patients but was not observed (0%) in controls. B*44032 was associated with a decreased risk. Five out of 54 (9%) NPC patients had B*44032 compared to 14/49 (29%) in the control group.

引用

页码：223 / 225

页数：3

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