PRDM5 is silenced in human cancers and has growth suppressive activities

被引：85

作者：

Deng, QD ^{[1
]}

Huang, S ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

ONCOGENE | 2004年 / 23卷 / 28期

基金：

美国国家卫生研究院;

关键词：

PRDM5 (PRDM5); PR/SET domain; tumor suppressors; 4q25-q26; PRDM2;

D O I：

10.1038/sj.onc.1207615

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several genes that contain the PR (PRDI-BF1 and RIZ) domain have been linked with human cancers. We describe here a new PR-domain-containing gene designated as PRDM5 (PFM2). A PRDM5 cDNA was isolated based on its homology to the PR domain of RIZ1 (PRDM2). The gene encodes an open reading frame of 630 amino acids and contains a PR domain in the NH-terminal region followed by 16 zinc finger motifs. Radiation hybrid analysis mapped PRDM5 to human chromosome 4q26, a region thought to harbor tumor suppressor genes for breast, ovarian, liver, lung, colon, and other cancers. The gene has a CpG island promoter and is silenced in human breast, ovarian, and liver cancers. A recombinant adenovirus expressing PRDM5 caused G2/M arrest and apoptosis upon infection of tumor cells. These results suggest that inactivation of PRDM5 may play a role in carcinogenesis.

引用

收藏

页码：4903 / 4910

页数：8

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