Effect of acute ethanol administration on zebrafish tail-beat motion

被引：17

作者：

Bartolini, Tiziana ^{[1
]}

Mwaffo, Violet ^{[1
]}

Butail, Sachit ^{[2
]}

Porfiri, Maurizio ^{[1
]}

机构：

[1] NYU, Polytech Sch Engn, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA

[2] Delhi IIITD, Indraprastha Inst Informat Technol, New Delhi 110020, India

来源：

ALCOHOL | 2015年 / 49卷 / 07期

基金：

美国国家科学基金会;

关键词：

Ethanol; Locomotion; Tail-beat amplitude; Tail-beat frequency; Zebrafish; BEHAVIORAL-RESPONSES; LARVAL ZEBRAFISH; DANIO-RERIO; EXPOSURE; TRACKING; FISH; COORDINATION; ONTOGENY; MODEL; SIZE;

D O I：

10.1016/j.alcohol.2015.06.004

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Zebrafish is becoming a species of choice in neurobiological and behavioral studies of alcohol-related disorders. In these efforts, the activity of adult zebrafish is typically quantified using indirect activity measures that are either scored manually or identified automatically from the fish trajectory. The analysis of such activity measures has produced important insight into the effect of acute ethanol exposure on individual and social behavior of this vertebrate species. Here, we leverage a recently developed tracking algorithm that reconstructs fish body shape to investigate the effect of acute ethanol administration on zebrafish tail-beat motion in terms of amplitude and frequency. Our results demonstrate a significant effect of ethanol on the tail-beat amplitude as well as the tail-beat frequency, both of which were found to robustly decrease for high ethanol concentrations. Such a direct measurement of zebrafish motor functions is in agreement with evidence based on indirect activity measures, offering a complementary perspective in behavioral screening. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：721 / 725

页数：5

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