The eye photoreceptor protein rhodopsin. Structural implications for retinal disease

被引：32

作者：

Garriga, P

Manyosa, J

机构：

[1] Univ Politecn Cataluna, Dept Engn Quim, Seccio Terrassa, Terassa 08222, Catalonia, Spain

[2] Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Unitat Biofis, Bellaterra 08193, Catalonia, Spain

来源：

FEBS LETTERS | 2002年 / 528卷 / 1-3期

关键词：

rhodopsin; retinitis pigmentosa; congenital stationary night blindness; misfolding; constitutive activity;

D O I：

10.1016/S0014-5793(02)03241-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhodopsin is the membrane receptor responsible for photoreception in the vertebrate retina. Its characteristic seven-transmembrane helical structural motif is today widely recognised as a paradigm in signal transduction. Rhodopsin and the phototransduction system are frequently used as structural and mechanistic models for the G-protein coupled receptor superfamily. Recent advances in the activation mechanism (as derived from the structural available data) and the implications for normal and pathological - in retinal disorders - visual function will be reviewed. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：17 / 22

页数：6

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