Mernapsin 2 (β-secretase) as a therapeutic target

被引：22

作者：

Hong, L

Turner, RT

Koelsch, G

Ghosh, AK

Tang, J

机构：

[1] Oklahoma Med Res Fdn, Prot Studies Program, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Ctr Med, Dept Biochem & Mol Biol, Oklahoma City, OK 73104 USA

[3] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷

关键词：

Alzheimer's disease; amyloid-beta peptide; beta-amyloid precursor protein; inhibitor drug;

D O I：

10.1042/bst0300530

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As beta-secretase, memapsin 2 cleaves amyloid-beta precursor protein, which leads ultimately to the onset of Alzheimer's disease. As such, memapsin 2 is an excellent target of inhibitor drugs for the treatment of this disease. Here we describe the tools for memapsin 2 inhibitor design that have been developed and results from the structure-based inhibitor design. Strategy for the design of memapsin 2 inhibitors with pharmaceutical potential is also discussed.

引用

页码：530 / 534

页数：5

共 21 条

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