Synthesis of sodium androst-5-ene-17-one-3 beta-methylene sulfonate

被引:5
作者
Chu, GH [1 ]
Li, PK [1 ]
机构
[1] DUQUESNE UNIV,GRAD SCH PHARMACEUT SCI,DIV MED CHEM,PITTSBURGH,PA 15282
关键词
steroids; steroid sulfatase; memory enhancement; dehydroepiandrosterone sulfate;
D O I
10.1016/S0039-128X(97)00039-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis of sodium androst-5-ene-17-one-3 beta-methylene sulfonate 2, a stable analog of memory-enhancing neurosteroid dehydroepiandrosterone sulfate, is described. The synthesis of compound 2 is carried out in six steps from dehydroepiandrosterone. (C) 1997 by Elsevier Science Inc.
引用
收藏
页码:543 / 545
页数:3
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