DIFFERENCES IN EXCITABILITY PROPERTIES OF FDI AND ADM MOTOR AXONS

被引：48

作者：

Bae, Jong Seok ^{[1
,2
]}

Sawai, Setsu ^{[1
]}

Misawa, Sonoko ^{[1
]}

Kanai, Kazuaki ^{[1
]}

Isose, Sagiri ^{[1
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Dept Neurol, Grad Sch Med, Chuo Ku, Chiba 2608670, Japan

[2] Inje Univ, Dept Neurol, Busan Paik Hosp, Coll Med, Pusan, South Korea

来源：

MUSCLE & NERVE | 2009年 / 39卷 / 03期

关键词：

amyotrophic lateral sclerosis; latent addition; nerve excitability; sodium channel; strength-duration time constant; AMYOTROPHIC-LATERAL-SCLEROSIS; THRESHOLD TRACKING TECHNIQUES; PERSISTENT NA+ CURRENTS; HUMAN PERIPHERAL-NERVE; UNIT NUMBER ESTIMATE; LATENT ADDITION; SPLIT HAND; DISEASE; ALS;

D O I：

10.1002/mus.21107

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The first dorsal interosseclus (FDI) and abductor digiti minimi (ADM) muscles are innervated by the same ulnar nerve, but studies have shown that the former is much more severely affected in amyotrophic lateral sclerosis. In this study, threshold tracking was used to investigate whether membrane properties differ between FDI and ADM motor axons. In 12 normal subjects, compound muscle action potentials were recorded from FDI and ADM after ulnar nerve stimulation at the wrist. The strength-duration time constant was significantly longer in the FDI axons than in the ADM axons, and latent addition studies showed greater threshold changes at the conditioning-test stimulus of 0.2 ms in FDI than in ADM axons. These findings suggest that nodal persistent sodium conductances are more prominent in FDI axons than in ADM axons, and therefore excitability is physiologically higher in FDI axons. Even in the same nerve at the same sites, membrane properties of FDI and ADM motor axons differ significantly, and thus their axonal/neuronal responses to disease may also differ. Muscle Nerve 39: 350-354, 2009

引用

页码：350 / 354

页数：5

共 27 条

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2-0

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