MicroRNA in autoimmunity and autoimmune diseases

被引：410

作者：

Pauley, Kaleb M. ^{[1
,2
]}

Cha, Seunghee ^{[1
,2
]}

Chan, Edward K. L. ^{[1
]}

机构：

[1] Univ Florida, Dept Oral Biol, Gainesville, FL 32610 USA

[2] Univ Florida, Dept Oral Surg & Diagnost Sci, Gainesville, FL 32610 USA

来源：

JOURNAL OF AUTOIMMUNITY | 2009年 / 32卷 / 3-4期

关键词：

MicroRNA; Autoimmunity; Immune response; Rheumatiod arthritis; Systemic lupus erythematosus; RHEUMATOID-ARTHRITIS; NUCLEAR EXPORT; POSTTRANSCRIPTIONAL REGULATION; REVISED CRITERIA; HIGH EXPRESSION; RNA; GENE; CELLS; PROTEINS; COMPLEX;

D O I：

10.1016/j.jaut.2009.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MicroRNAs (miRNAs) are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 31 untranslated region (UTR) of specific messenger RNAs (mRNAs) for degradation or translational repression. miRNA-mediated gene regulation is critical for normal cellular functions such as the cell cycle, differentiation, and apoptosis, and as much as one-third of human mRNAs may be miRNA targets. Emerging evidence has demonstrated that miRNAs play a vital role in the regulation of immunological functions and the prevention of autoimmunity. Here we review the many newly discovered roles of miRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. Specifically, we discuss the involvement of miRNA regulation in innate and adaptive immune responses, immune cell development, T regulatory cell stability and function, and differential miRNA expression in rheumatoid arthritis and systemic lupus erythematosus. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：189 / 194

页数：6

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