A facile KF/Al2O3 mediated, selective alkylation of benzodiazepin-2,5-diones

被引：14

作者：

Blass, BE ^{[1
]}

Burt, TM ^{[1
]}

Liu, S ^{[1
]}

Portlock, DE ^{[1
]}

Swing, EM ^{[1
]}

机构：

[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)00115-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a new, versatile method for the selective alkylation of benzodiazepin-2,5-diones using KF on Al2O3 The use of a reagent on a solid support makes this process suitable for the preparation of combinatorial libraries. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2063 / 2066

页数：4

共 17 条

[1] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 3,5-DISUBSTITUTED 4,5-DIHYDRO-6H-IMIDAZO[1,5-A][1,4]BENZODIAZEPIN-6-ONES AT DIAZEPAM-SENSITIVE AND DIAZEPAM-INSENSITIVE BENZODIAZEPINE RECEPTORS [J].

ANANTHAN, S ;

CLAYTON, SD ;

EALICK, SE ;

WONG, G ;

EVONIUK, GE ;

SKOLNICK, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (04) :479-490

[2]

BAUER A, Patent No. 3914216

[3] A facile KF/Al2O3 mediated method for the synthesis of substituted oxazolidinones [J].

Blass, BE ;

Drowns, M ;

Harris, CL ;

Liu, S ;

Portlock, DE .

TETRAHEDRON LETTERS, 1999, 40 (36) :6545-6547

[4]

CHO NS, 1989, J HETEROCYCLIC CHEM, V26, P1807

[5]

ELLMAN JA, 1994, Patent No. 5288514

[6]

JONES GB, 1990, ANTI-CANCER DRUG DES, V5, P249

[7] A remarkable two-step synthesis of diverse 1,4-benzodiazepine-2,5-diones using the Ugi four-component condensation [J].

Keating, TA ;

Armstrong, RW .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (25) :8935-8939

[8]

MARTINO GD, 1983, EUR J MED CHEM, V18, P347

[9] FROM PEPTIDE TO NONPEPTIDE .2. THE DE-NOVO DESIGN OF POTENT, NON-PEPTIDAL INHIBITORS OF PLATELET-AGGREGATION BASED ON A BENZODIAZEPINEDIONE SCAFFOLD [J].

MCDOWELL, RS ;

BLACKBURN, BK ;

GADEK, TR ;

MCGEE, LR ;

RAWSON, T ;

REYNOLDS, ME ;

ROBARGE, KD ;

SOMERS, TC ;

THORSETT, ED ;

TISCHLER, M ;

WEBB, RR ;

VENUTI, MC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (12) :5077-5083

[10]

NGUYEN HD, 1985, C R ACAD SCI SER 2, V300, P799

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