Oligomeric thioglycosides with α-D-manno-(1′→2) linkages from a glycal-1,2-episulfide

被引：15

作者：

Knapp, S ^{[1
]}

Malolanarasimhan, K ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem, Piscataway, NJ 08854 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 04期

关键词：

D O I：

10.1021/ol990702x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Under basic conditions, phenyl 1,2-dithio-alpha-D-mannopyranoside farms a glycal-1,2-episulfide, which undergoes controlled oligomerization to afford a family of thio-oligo-alpha-D-mannopyranosides in a single reaction. The episulfide can also be intercepted by added thiolates, which leads to other sorts of thioglycosides. These alpha-(1-->2)- linked thio-mannopyranosides might have application as mimics of natural structures such as viral high mannose glycoproteins or ManLAM.

引用

页码：611 / 613

页数：3

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