A consensus epitope prediction approach identifies the breadth of murine TCD8+-cell responses to vaccinia virus

被引：424

作者：

Moutaftsi, Magdalini

Peters, Bjoern

Pasquetto, Valerie

Tscharke, David C.

Sidney, John

Bui, Huynh-Hoa

Grey, Howard

Sette, Alessandro

机构：

[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92109 USA

[2] Queensland Inst Med Res, Div Infect Dis & Immunol, Herston, Qld 4006, Australia

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 07期

关键词：

D O I：

10.1038/nbt1215

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2(b) mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.

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收藏

页码：817 / 819

页数：3

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